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KMID : 0369819930230010033
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Jorunal of Korean Pharmaceutical Sciences
1993 Volume.23 No. 1 p.33 ~ p.39
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The Effect of Cholesterol on the Property of Vesicle
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조의환/Cho IH
문권기/신재섭/Moon KG/Shin JS
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Abstract
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Polymerized vesicles were prepared from monomeric cholesterol-containing surfactant. These vesicles were used to extract the free cholesterol. To introduce spacer group into [cholesteryloxycarbonylmethyl] [2-(methacryloyloxy)ethyl]dimethylammonium chloride (CHODAMA), [5-[ (cholesteryloxy)carbonyl]pentyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-5) and [10-[(cholesteryloxy)carbonyl]decyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-10) were synthesized, In both case of polymerized vesicle with CHODAMA-5 and CHODAMA-10, the permeability was decreased and the amount of extracted cholesterol was also decreased, compared with the polymerized vesicle of CHODAMA.
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KEYWORD
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Vesicle, Polymerized vesicle, Cholesterol
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